Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3891 | CA17088 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 156 |
| 2 | DDI | 60 |
| 3 | D4T | 26 |
| 4 | AZT | 8 |
| 5 | 3TC+D4T | 17 |
| 6 | 3TC+AZT+RTV | 13 |
| 7 | 3TC+AZT+IDV | 35 |
| 8 | 3TC+D4T+IDV | 25 |
| 9 | D4T+DDC+NFV | 52 |
| 10 | ABC+EFV+RTV | 30 |
| 11 | 3TC+ABC+AZT+NFV | 66 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90LM | Q58E | L10I, I15V, K20R, E35D, M36I, N37E, L63P |
| >CA17088| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEDIELPGRWKPKMIGGIGGFVKVREYD QIPIEICGHKAIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, M184V, L210W, T215Y | V60I, I135T, I142V, V179VG, R211K, V245K, I293V | A299AG |
| >CA16843| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIGI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEGE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |