Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1836 | CA17076 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ D4T+ DDC+ DDI | NA |
| 2 | IDV+ NFV+ RTV | NA |
| 3 | D4T+ DLV+ NFV | NA |
| 4 | 3TC+ D4T+ RTV+ SQV | 24 |
| 5 | 3TC+ D4T+ NFV+ SQV | 7 |
| 6 | 3TC+ ABC+ NFV+ SQV | 24 |
| 7 | None | 7 |
| 8 | 3TC+ AZT+ NVP+ IDV+ RTV | 33 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10I, K20R, E35D, M36I, I62V, L63P, A71V, T74S, I93L |
| >CA17076| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVIGSVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | K103N | V35R, K46KQ, D123E, D177E, T200I, I202V, R211K, N265X, A272P, I293V |
| >CA16968| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICTEMEKEGQISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRIKVEELRQHLLKWGFTTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLXWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEA |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |