Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1860 | CA17064 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 209 |
| 2 | 3TC+AZT+IDV | 58 |
| 3 | D4T+DDI+RTV+SQV | 36 |
| 4 | 3TC+D4T+DDI+EFV | 90 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10I, I13V, K14R, R41K, K55R, L63P, A71V |
| >CA17064| codons 1-99 PQITLWQRPIVTVRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFVRVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74IV, M184I, T215F | K219Q | G190E | A98G | K20R, V35E, T39A, V60I, K101R, K103R, V118I, K122E, I135K, F214L, L228H, I293V, E297K, T386I, K390R, A400T, V435A, A437V, V466I, V467I, K527NS, A554T | A360AP, Q509Y |
| >CA16956| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALEEICAELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLRKRKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYIDDLYVESDLEIGQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGP HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGVETFYVDGAANRETKLGKAGYVTDRGRQKIISLTDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAYPDKSESELVSQIIEQLISKEKVYLAWVPAHK GIGGNEQVDKLVSTGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |