<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA6834 CA17006 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T+3TC+SQV 108
2 3TC+D4T+IDV 177

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L76V, L90M L33LI L10I, K20I, M36I, I62V, L63P, C67CF, A71V, I85V, I93L  
>CA17006| codons 1-99
PQITLWQRPIVTIKIGGQLIEALLDTGADDTVIEEINLPGRWKPKIIGGIGGFIKVRQYD
QVPIEIFGHKVIGTVVVGPTPVNIVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219KN     K22KN, K43KQ, E44ED, T69TA, V118I, K122E, D123DN, T200A, H208Y, R211K, L228LH, V245E  
>CA16897| codons 1-276
PISPIETVPVKLKPGMDGPKVNQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV
FAIKKKNSAKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELRQYLWKWGFYTPDNKHQKEPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKV

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005