Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA628 | CA17003 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 17 |
| 2 | AZT+DDC | 4 |
| 3 | AZT+D4T | 17 |
| 4 | 3TC+AZT+D4T | 17 |
| 5 | 3TC+AZT+SQV | 44 |
| 6 | 3TC+D4T+IDV | 48 |
| 7 | D4T+DDI+RTV+SQV | 32 |
| 8 | DDI+RTV+SQV | 4 |
| 9 | None | 1 |
| 10 | DDI+Unknown | 29 |
| 11 | D4T+DDI+Unknown | 5 |
| 12 | D4T+DDI | 1 |
| 13 | None | 48 |
| 14 | ABC+APV+D4T+EFV+RTV | 24 |
| 15 | None | 2 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A, I84V, L90M | L23I, Q58E | L10I, D60E, Q61EK, L63P, A71T, I72T |
| >CA17003| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVREYE EIPIEICGHKTTGTVLVGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | G190E | K20R, V35I, E36EK, K43N, I135V, T200A, A272P, K277R |
| >CA16894| codons 1-278 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIKICTELENEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVESDLEIGQHRAKIEELRQHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQ |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |