Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1825 | CA16946 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 56 |
| 2 | AZT+DDI | 117 |
| 3 | AZT+DDI+IDV | 9 |
| 4 | 3TC+D4T+NFV | 73 |
| 5 | 3TC+APV+D4T+NFV | 71 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K43Q, S68G, V118I, K122KE, I135IV, Q174R, T200A, Q207E, R211RK, E224ED, A272P, E291D, D324E, G333E, Q334H, T338S, K390R, A400T, T403TM, D460N, V466VI, V467VI, T470TP, L491LS, S519N, Q524QE, E529D, K530R, I556V, K558R |
| >CA16946| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKDPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQEHGQWSYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWETWWMEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKIISLPDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEELIKKDRVYLAWVPAHK GIGGNEQVDKLVSAGVRRVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, L90M | L33F, Q58E, G73A | L10I, L19X, I54X, L63P, H69HY, A71T, I72T, V77I, I93L |
| >CA17054| codons 1-99 PQITLWQRPIVTIKIGGQXKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFXKVREYD QIPIEICGYKTTATVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |