Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3978 | CA16918 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 57 |
| 2 | 3TC+AZT | 22 |
| 3 | 3TC+AZT+IDV | 74 |
| 4 | DDI+NFV+NVP | 61 |
| 5 | D4T+NVP+SQV | 21 |
| 6 | APV+D4T+NVP+SQV | 39 |
| 7 | 3TC+ABC+DDI+LPV | 12 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K101E, Y181C, G190A | P14PS, E28K, K32E, V35L, T39A, K43E, E44D, V118I, K122E, I135T, G196E, R211K, V245Q, I293V, E297K | N54NI |
| >CA16918| codons 1-303 PISPIETVPVKLKSGMDGPKVKQWPLTKEKIEALLEICAELEEDGKISKIGPEIPYNTPV FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | G73T | L10I, N37D, K55R, L63P, A71V, I93L |
| >CA17025| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFVRVRQYD QIPIEICGHKVITTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |