Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA641 | CA16882 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | AZT+DDI | 117 |
| 3 | 3TC+AZT | 31 |
| 4 | 3TC+AZT+IDV | 26 |
| 5 | 3TC+D4T+IDV | 27 |
| 6 | 3TC+D4T+RTV+SQV | 78 |
| 7 | DDI+EFV+Unknown | 24 |
| 8 | D4T+IDV+RTV | 87 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | L100I, K103N | P4PS, E28EK, V35M, T39S, E44D, V118I, K122E, T200A, E203K, Q207D, H208Y, R211K, K223E, L228H |
| >CA16882| codons 1-257 PISSIETVPVKLKPGMDGPKVKQWPLTKEKIKALMEICSELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKIKELRDYLWKWGFYTPDKKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDI |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | F53L, L89V | L10I, L33M, N37C, I62V, L63P, A71V, C95CS |
| >CA16989| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTIMEEMCLPGRWKPKIIGGIGGLVKVRQYD QVPIEICGHKVIGTVLVGPTPANIIGRNVMTQIGSTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |