Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4334 | CA16860 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 26 |
| 2 | 3TC+D4T+IDV | 52 |
| 3 | DDI+DLV+RTV+SQV | 52 |
| 4 | D4T+ADV+EFV+RTV+SQV | 21 |
| 5 | None | 26 |
| 6 | ABC+D4T+APV+NFV | 26 |
| 7 | 3TC+ABC+D4T+APV | 26 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74LV, M184MV, L210W, T215DY | K219N | M230ML | V179VD | T39E, R83K, K103R, V118VI, K122KE, S162C, K173KR, I178IM, G196GE, E203D, H208HY, R211K, V245Q, T286A, V292I |
| >CA16860| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRRQNPDMDI YQYVDDLYVGSDLEIEQHRTKIDELRQYLWKWGFDTPDNKHQKEPPFLWLGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEIIPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV, I84IV, L90LM | L33LI | L10LI, L19LI, K20X, E35D, M36MI, N37D, L63P, A71IT, Q92QK |
| >CA17100| codons 1-99 PQITLWQRPIVTIKIGGQIXEALLDTGADDTVIEDIDLPGRWKPKMIGGIGGFVKVRQYD QIPIEICGHKIIGTVLVGPTPVNVIGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |