Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6807 | CA16858 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 22 |
| 2 | 3TC+AZT+IDV | 100 |
| 3 | D4T+DDI+NFV | 22 |
| 4 | EFV+RTV+SQV | 26 |
| 5 | APV+DDI+EFV+RTV | 48 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L210CW, T215Y | K219E | M230L | V179D | K13X, K22KN, V106L, V118I, D123E, I135T, S162C, Q174E, H208Y, R211K, K223Q, L228R, K281KR, I293V |
| >CA16858| codons 1-300 PISPIETVPVKLXPGMDGPKVNQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSLTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKENPDIDI YQYMDDLYVGSDLEIGQHRTKIEELRQYLCKWGFYTPDEKHQQEPPFRWLGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | Q7QK, E35D, M36I, R41K, L63P, I64V, I72V, V77I | L5LGRV |
| >CA212928| codons 1-99 PQITVWKRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QIPVEICGHKAVGTVLIGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |