Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6802 | CA16848 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 104 |
| 2 | 3TC+DDC+SQV | 13 |
| 3 | 3TC+DDC+IDV | 21 |
| 4 | NVP | 43 |
| 5 | 3TC+AZT+NVP+SQV | 56 |
| 6 | AZT+3TC+NVP+SQV | 17 |
| 7 | ABC+DDI+EFV+IDV | 17 |
| 8 | None | 39 |
| 9 | D4T+NVP+RTV+SQV | 23 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K101E, Y181C, G190A | K20R, V35I, K43E, E44A, V90VI, V118I, K122E, S134SR, I135T, T165I, D177E, I178M, V179VG, G196E, Q207E, R211K, A272P, K277R | T286AG |
| >CA16848| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPRTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPEMGI CQYMDDLYVASDLEIEQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54A, V82A, L90M | L10I, L19T, I62V, L63P, A71V, V77I, I93L |
| >CA17093| codons 1-99 PQITLWQRPIVTIKIGGQTKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFAKVRQYD QVPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |