<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA6802 CA16848 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+DDC 104
2 3TC+DDC+SQV 13
3 3TC+DDC+IDV 21
4 NVP 43
5 3TC+AZT+NVP+SQV 56
6 AZT+3TC+NVP+SQV 17
7 ABC+DDI+EFV+IDV 17
8 None 39
9 D4T+NVP+RTV+SQV 23

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y   K101E, Y181C, G190A   K20R, V35I, K43E, E44A, V90VI, V118I, K122E, S134SR, I135T, T165I, D177E, I178M, V179VG, G196E, Q207E, R211K, A272P, K277R T286AG
>CA16848| codons 1-303
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPRTNNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPEMGI
CQYMDDLYVASDLEIEQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE
LEL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54A, V82A, L90M   L10I, L19T, I62V, L63P, A71V, V77I, I93L  
>CA17093| codons 1-99
PQITLWQRPIVTIKIGGQTKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFAKVRQYD
QVPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Gonzales, MJ HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. J Infect Dis, 2001
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005