Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6796 | CA16841 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 30 |
| 2 | D4T | 70 |
| 3 | 3TC+D4T+DDI+IDV | 65 |
| 4 | D4T+NFV+NVP | 28 |
| 5 | 3TC+D4T+IDV | 6 |
| 6 | 3TC+AZT+D4T+IDV | 18 |
| 7 | DDI+NFV+SQV | 34 |
| 8 | EFV+RTV+SQV | 9 |
| 9 | 3TC+APV+D4T | 9 |
| 10 | 3TC+APV+D4T+DDI | 20 |
| 11 | ABC+APV+RTV | 9 |
| 12 | 3TC+DDI+IDV | 21 |
| 13 | 3TC+D4T+DDI+LPV | 12 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74LI, M184V, L210W, T215Y | K219R | K103N | A98G | T39D, E44D, V118I, K122E, I142V, S162C, V179I, G196E, I202V, R211K, L228H, V245M, A272P, I293V, E297R |
| >CA16841| codons 1-302 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICDELEKDGKISKIGPENPYNTPV FAIKKKDSDKWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIEQHRTKVEELRQHLWKWGFYTPDRKHQKEPPFHWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTREAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | V11I, G73T | L10I, I13V, K20I, M36I, I62V, L63P, A71V |
| >CA17086| codons 1-99 PQITLWQRPIITVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVITTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |