<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
SA-140857b SA-140857b U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 18
2 AZT+DDC+SQV 42
3 AZT+SQV 16
4 AZT+DDC+SQV 17
5 AZT+SQV 65
6 AZT+DDC+SQV 4
7 3TC+AZT+DDC+SQV 10
8 3TC+AZT+SQV 9

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54IV, V82A F53FL L10I, K14R, L19LI, L63A, A71AV, I72V, T74S, V77I  
>SA-140857b| codons 1-99
PQITLWQRPIVTIRIGGQIKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGLVKVRQYD
QIAIEICGHKVVGSVLIGPTPANIIGRNLLTQIGCTLNF

References
Author Title Citation
Sevin, AD Methods for investigating the relationship between drug-susceptibility phenotype and HIV-1 genotype with applications to ACTG 333. J Infect Dis, 2000
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005