Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5177 | CA16565 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T | 57 |
| 2 | 3TC+D4T+IDV | 35 |
| 3 | AZT+DDC+NFV | 26 |
| 4 | AZT+DDI+RTV+SQV | 17 |
| 5 | 3TC+ABC+EFV | 26 |
| 6 | 3TC+D4T+IDV+RTV | 43 |
| 7 | 3TC+ABC+D4T+IDV+RTV | 17 |
| 8 | 3TC+ABC+AZT+EFV | 7 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, L90M | F53L | I15V, K20M, M36I, L63P, I66F, A71V |
| >CA16565| codons 11-99 VTIKVGGQLMEALLDTGADDTVLEEINLPGRWKPKMIGGIGGLVKVRQYDQIPIEFCGHK VIGTVLVGPTPTNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | A62V, V75I, F77L, F116Y | K49KR, K122E, V245I, E248D, V276VI, Q278H, K281R, L283I, T286A, I293V, F346Y, R356K, K390R, E432D, L491S, K527Q, A554S | A299AG |
| >CA16470| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISRIGPENPYNTPV FVIKRKDSTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIILPDKDSWTVNDIQKLVGKLNWASQIYAGIKIKHLCRLIRGAKALTEVVPLTEEGE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPYKNLKTGKYAKMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEAWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKDPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIQKEKVYLAWVPAHK GIGGNEQVDKLVSSGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |