Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6485 | CA16550 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 28 |
| 2 | 3TC+AZT | 67 |
| 3 | 3TC+AZT+IDV | 28 |
| 4 | 3TC+AZT+RTV+SQV | 14 |
| 5 | 3TC+D4T+NFV+SQV | 40 |
| 6 | D4T+NFV+SQV | 43 |
| 7 | 3TC+AZT+DDI+IDV | 14 |
| 8 | EFV+ABC+NFV+SQV | 31 |
| 9 | 3TC+ABC+D4T+APV | 25 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | V11I, G73S | L10I, I15V, K20I, E35D, I62V, L63P, A71V, P79A, I85IV |
| >CA16550| codons 1-99 PQITLWQRPIITIKVGGQLIEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLVGATPVNVVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75M, M184V, T215F | K219E | L100I, K103N | K20R, V60I, T69TN, K122E, D177N, T200I, R211K, D218E, L228H, A272P, K277R, A288AS |
| >CA16455| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKIMDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYVDDLYVGSDLEIGQHRIKIEELRQHLLKWGFFTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKSLTEVIPLTEEAE LEL |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |