Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6591 | CA16531 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 8 |
| 2 | AZT+DDC | 43 |
| 3 | AZT | 21 |
| 4 | D4T | 17 |
| 5 | AZT+3TC | 26 |
| 6 | AZT+3TC+RTV | 8 |
| 7 | AZT+3TC | 43 |
| 8 | D4T+DDI+NFV | 17 |
| 9 | AZT+DDI+3TC | 78 |
| 10 | DDC+DDI+EFV+3TC | 21 |
| 11 | D4T+3TC+RTV+SQV | 46 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | F53L | L10V, I15V, R41K, L63P, V77I |
| >CA16531| codons 1-99 PQITLWQRPVVTIKVGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGLVKVRQYD QIPIEICGHKAIGTVLIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | V35M, T39A, K43Q, E44D, S68G, V118I, K122E, D123N, I135T, R211K, A272P, K277R |
| >CA16435| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEQDGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |