<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1588 CA16511 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ DDI+ DLV 20
2 3TC+ D4T+ SQV 15
3 3TC+ AZT+ IDV 97
4 D4T+DDI+NVP+RTV+SQV 8
5 D4T+DDI+NFV+SQV 109

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I54V, V82A, I84IV L24LI L10I, K14KR, R41K, K55KR, I62V, L63P, I64V, T74S, I93IL  
>CA16511| codons 1-99
PQITLWQRPIVTIRIGGQLKEALIDTGADDTVLEEMNLPGKWKPKIIGGIGGFVRVRQYD
QVPVEICGHKAIGSVLVGPTPANVIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T215SY K219R K103N   E6D, T39AE, E44ED, T165TA, K173N, E203ED, R211RK, A272P A299AG
>CA16398| codons 1-303
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMAKILEPFRNQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIDELRQHLLKWGFSTPDRKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEGE
LEL

References
Author Title Citation
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005