Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6585 | CA16507 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 6 |
| 2 | D4T+DDI+RTV+SQV | 17 |
| 3 | ABC+EFV+NFV+NVP | 41 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73S | L10V, T12D, I15V, K20V, D60E, Q61D, I62V, L63P, C67Y, H69K, A71V, I72L, V77I |
| >CA16507| codons 1-99 PQITLWQRPVVDIKVGGQLVEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYE DVPIEIYGKKVLSTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K103KN, Y181C, Y188Y*FL, G190GA | A98G | K20KR, T39TA, K43KQ, E44D, V118I, K122E, I135T, G196E, E203K, Q207E, H208Y, R211K, K223Q, V245E, A272P, T286A, A288AT, I293V, E297K | A299AG |
| >CA16426| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLLVASDLEIEQHRTKIKELREYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKTLTEVVPLTKEGE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |