<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
046H 046H Afghanistan 2006 HIV1 CRF35_AD PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, L19Q, K20R, E35D, M36I, R41K, R57K, I62V, L63I, H69K, L89M  
>046H| codons 1-99
PQITLWQRPLVTVKIGGQQREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QVIIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6DN, V8I, K11R, V35T, V60I, D121Y, K122E, D123DN, I135R, R172RK, Q174H, D177E, V179I, E194EK, T200I, Q207A, R211K, V245E, D250E, A272P, L283I, E291D, V292I, I293V, P294S, G335D, R356K, M357K, G359S, E370D, A371V, I375V, A376T, K390R, A400T, T403M, E404D, E432D, R463RK, D471E, Q480H, L491S, L517V, S519N, Q524K, I526V, K527E, E529D, A534S, A554S D443DN
>046H| codons 1-560
PISPINTIPVRLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
YENFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKHNPEIII
YQYMDDLYVGSDLKIGQHRIKIEELRAHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTDIVSLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA
HTNDVKQLTDVVQKVTTESIVIWGKTPKFRLPIQKETWETWWMDYWQATWIPEWEFVNTP
PLVKLWYQLEKDPIVGAETFYVNGAANRETKLGKAGYVTDRGKQKVVSLTETTNQKTELH
AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESEVVNQIIEKLVEKDKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, A21AT, E35Q, S39N, I60M, I72V, T112V, I113V, T125A, V126F, G134S, K136Q, D167E, V201I W19W*, S283G
>046H| codons 1-288
FLDGIDKAQEEHERYHSN*RTMASDFNLPPVVAKQIVANCDKCQLKGEAMHGQVDCSPGM
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN
FTSTAFKAACWWASIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

References
Author Title Citation
Sanders-Buell, E Distinct circulating recombinant HIV-1 strains among injecting drug users and sex workers in Afghanistan. ARHR, 2010