<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
051H 051H Afghanistan 2006 HIV1 CRF35_AD PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, L19Q, K20R, E35D, M36I, R41K, R57K, L63I, H69K, L89M  
>051H| codons 1-99
PQITLWQRPLVTVKIGGQQREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QIIIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6D, V8I, K11R, V35T, V60I, D121Y, K122E, I135R, Q174H, D177E, V179I, T200I, Q207A, R211K, V245E, D250E, A272P, L283I, E291D, V292I, I293V, P294S, G335D, R356K, M357K, G359S, T369A, E370D, A371V, I375V, A376T, T377M, K390R, A400T, T403M, E404D, D471E, T477A, Q480H, L491S, L517V, S519N, Q524K, I526V, K527E, E529D, A534S, A554S T216A
>051H| codons 1-560
PISPIDTIPVRLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPEIII
YQYMDDLYVGSDLEIGQHRIKIEELRAHLLKWGFTAPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTDIVSLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA
HTNDVKQLADVVQKVTMESIVIWGKTPKFRLPIQKETWETWWMDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTDRGRQKVVSLTETTNQKAELH
AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESEVVNQIIEKLVEKDKVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    K14R, E35Q, S39N, I60M, I72V, T112V, I113V, T125A, V126F, G134S, K136Q, D167E, V201I S283G
>051H| codons 1-288
FLDGIDKAQEEHERYHSNWRAMASDFNLPPVVAKQIVANCDKCQLKGEAMHGQVDCSPGM
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSN
FTSTAFKAACWWASIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

References
Author Title Citation
Sanders-Buell, E Distinct circulating recombinant HIV-1 strains among injecting drug users and sex workers in Afghanistan. ARHR, 2010