Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| R449 | ZZR449 | Nigeria | 2007 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC|AZT|NVP|EFV | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219E | K103KN, V106A | K101KHNQ | V35T, V60I, T69TN, K122P, D123S, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, T215X, V245Q, E248D, D250E, A272P, T286TA, E291D, V292I, I293V, D324E, I329V |
| >ZZR449| codons 1-333 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSATVLDVGDAYFSVPL DPSFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPEMVI YQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLXTPDEKHQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEVQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, K20I, E35Q, M36I, N37D, R41K, R57K, L63LAPV, C67E, H69K, V82I, L89M |
| >ZZR449| codons 1-99 PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEQIDLPGKWKPKMIGGIGGFIKVKQYD QIVIEIEGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Hawkins, CA | Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. | JAIDS, 2009 |