<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
R444 ZZR444 Nigeria 2007 HIV1 CRF02_AG Plasma None

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K14R, K20I, E35N, M36I, N37D, R41K, H69K, L89M  
>ZZR444| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLENIDLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V A62V, V75IT K101E, G190A   I31L, V35T, E36D, T39N, E53D, D123E, I132IV, E138A, S162A, K173T, Q174R, D177E, T200A, Q207E, R211K, F214L, V245Q, A272P, K277R, T286A, E291ED, I293V, P294PT, S322T  
>ZZR444| codons 1-335
PISPIETVPVKLKPGMDGPKVKQWPLTEEKLKALTDICNEMEKEGKISKIGPDNPYNTPV
FVIKKKDSTKWRKLTDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTVPSINNATPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTRNPEIVI
YQYVDDLYVASDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDVVTLTEEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQG

References
Author Title Citation
Hawkins, CA Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. JAIDS, 2009