<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC|D4T|AZT|NVP NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74LV, M184I D67DG Y181C, G190S   V35T, V60I, T69S, K101Q, K122E, D123S, I135V, I142IV, S163ST, T165I, K173T, Q174K, D177E, T200A, I202IV, Q207N, V245Q, E248N, D250E, A272P, E291D, V292I, I293V, I329V  
>ZZR441| codons 1-333
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKGSSKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSTMIKILEPFRTKNPEIVI
CQYIDDLYVSSDLEIGQHRAKVEELRNHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPNKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L   I13V, K14R, K20I, E35Q, M36I, R41K, K55R, R57K, L63P, C67E, H69K, V82I, L89M  
>ZZR441| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEQINLPGKWKPKLIGGIGGFIRVKQYD
QIPIEIEGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF

References
Author Title Citation
Hawkins, CA Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. JAIDS, 2009