<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+TDF+NVP NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Y115F, M184V   V106A, Y181C   P4T, E6EK, V35T, E36D, T39I, K49R, S68SG, K122E, D123E, I135V, S162A, K173T, Q174QKR, D177E, T200A, Q207E, R211K, V245Q, D250E, S251H, L283I, E291D, V292I, I293V, P294T, L295M, S322T  
>ZZR266| codons 1-334
PISTIKTVPVKLKPGMDGPKVKQWPLTEEKIKALTDICIEMEKEGKISRIGPENPYNTPV
FAIKRKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSATVLDVGDAFFSVPL
DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTRNPEIVI
CQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKEHWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTDIVTMTEEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, G16GE, K20I, M36I, R41K, H69K, K70R, L89M  
>ZZR266| codons 1-99
PQITLWQRPLVTVKIEGQLIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Hawkins, CA Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. JAIDS, 2009