<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
R475 ZZR475 Nigeria 2007 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 3TC+D4T+NVP NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   Y181I   E6K, K20KR, K32I, V35T, T39K, K43E, T69N, K122E, I135V, T139TKR, I142V, S162AD, T165TI, F171Y, D177E, V179I, T200A, Q207A, R211K, F214L, V245Q, E248D, K281KR, T286A, E291D, I293V, P294T, I326V  
>ZZR475| codons 1-334
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIIALTEICKEMEEEGKISKIGPENPYNTPV
FAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSVNNERPGVRYQYNVLPQGWKGSPAIFQDSMIKILEPYRKQNPEIII
IQYVDDLYVGSDLEIGQHRAKIEELRAHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDVVTLTEEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    Q7E, L10I, I13V, I15IV, G16GE, K20KR, E35D, M36I, R41K, R57K, H69Q, L89M  
>ZZR475| codons 1-99
PQITLWERPIVTVKVEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYD
QILIEICGQKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Hawkins, CA Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. JAIDS, 2009