<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
R358 ZZR358 Nigeria 2007 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 NRTI|EFV NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K20I, M36I, R41K, L63H, C67G, H69K, V82I, L89I  
>ZZR358| codons 1-99
PQITLWQRPLVTVKIGGQLIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIHIEIGGKKAIGTVLVGPTPINIIGRNILTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
Y115F, M184V   K103N, Y188C   K20R, V35A, T39K, E40D, S105T, V106I, V118I, I135T, K173IM, Q174K, D177DE, I178L, T200A, Q207E, R211K, F214L, H221Y, V245Q, E248D, D250E, S251D, A272P, Q278QH, T286A, K287KR, V292I, I293V, E297A, L301M, I329V L210LQ
>ZZR358| codons 1-334
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALAEICKDMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKTITVLDVGDAFFSIPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRMKNPELVI
YQYVDDLCVGSDLEIGQHRAKIEELREHLQKWGLTTPDKKYQKEPPFLWMGYELHPDKWT
VQPIQLPDKEDWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGARALTEIVPLTAEAE
MELAENREILKEPVHGVYYDPSKDLIAEVQKQGQ

References
Author Title Citation
Hawkins, CA Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. JAIDS, 2009