Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| R253 | ZZR253 | Nigeria | 2007 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC|TDF|D4T|AZT|NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70E, M184V | K103S, Y181C | K20R, V35T, T39A, E40D, K104KR, V118I, K122E, D123N, I135T, S163C, E169D, K173T, Q174K, D177E, I178L, T200A, Q207E, F214L, L228R, V245Q, E248D, D250E, E291D, V292I, I293V, I329V |
| >ZZR253| codons 1-333 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICADMEKEGKISKIGPENPYNTPV FAIKKKDSTEWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKSRSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSCMTKILDPFRTKNPELVI CQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGLTTPDKKHQKEPPFRWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, K20I, E35Q, M36I, N37D, R41K, R57K, I62V, L63P, I64M, C67E, H69K, V82I, L89M |
| >ZZR253| codons 1-99 PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEQIDLPGKWKPKMIGGIGGFIKVKQYD QVPMEIEGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Hawkins, CA | Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. | JAIDS, 2009 |