<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+AZT+NVP NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215Y   V106A F227L V35T, T39K, K104R, L109I, K122E, D123S, S162SCT, K173A, Q174K, D177E, T200A, H208HY, R211EK, V245K, E248D, D250E, A272S, T286A, E291D, V292I, I293V, I329L S105Q
>ZZR252| codons 1-333
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRQATVIDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQTSMTKILEPFRAKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELRQYLLKWGFYTPDKKHQKEPPLLWMGYELHPDKWT
VQPIKLPDKESWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, K14R, K20I, E34EK, E35Q, M36I, N37D, R41K, R57K, L63P, I64M, C67E, H69K, V82I, L89M  
>ZZR252| codons 1-99
PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLKQIDLPGKWKPKMIGGIGGFIKVKQYD
QIPMEIEGKKAIGTVLVGPTPINIIGRNMLTQIGCTLNF

References
Author Title Citation
Hawkins, CA Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. JAIDS, 2009