Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| R351 | ZZR351 | Nigeria | 2007 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67DN, K70KR, M184V, T215F | K219KQ | K103N | A98G | K20R, V35T, V60I, S68SG, D123E, I135T, S162A, K173T, Q174A, D177E, G196E, T200A, Q207G, R211K, F214L, V245Q, E248D, A272P, L283I, T286A, E291D, V292I, I293V, S322T |
| >ZZR351| codons 1-333 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNGTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTANPEIVI YQYVDDLYVGSDLEIEQHRAKIEELRGHLLKWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, G17E, K20I, M36L, R41K, K43R, L63T, I64M, H69K, K70R, L89M |
| >ZZR351| codons 1-99 PQITLWQRPLVTVRIGEQLIEALLDTGADDTVLEELNLPGKWRPKMIGGIGGFIKVRQYD QITMEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Hawkins, CA | Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. | JAIDS, 2009 |