<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+AZT+NVP NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V, T215F   G190A, M230L K101H T7A, V35T, T39E, S48T, V60I, D121H, K122E, I135R, S162C, K173T, Q174KR, D177E, V179VI, T200A, Q207E, R211K, V245Q, A272P, K275Q, K277KR, L283I, E291D, V292I, I293V, Q334N  
>ZZR347| codons 1-335
PISPIEAVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSVPL
HEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTRNPEIII
YQYVDDLYVASDLEIGQHRAKIEELREHLLKWGFFTPDKKHQKEPPFLWLGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIQVRQLCKLIRGTKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNG

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, I15V, L19IV, K20R, M36I, R41K, L63Q, I64L, H69K, L89M, I93L  
>ZZR347| codons 1-99
PQITLWQRPLVTVKVGGQVREALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIQLEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Hawkins, CA Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. JAIDS, 2009