Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| R28 | ZZR28 | Nigeria | 2007 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+TDF+NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, M184V | K103N, Y181C | K20KR, T27S, V35T, E36D, T39K, K43KE, K49KR, V60I, S68G, V90VI, K122E, D123G, I135T, E138A, S162A, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, V245E, D250E, S251H, K281KR, T286A, E291D, I293V, P294T, L295M, K311KR, S322T |
| >ZZR28| codons 1-334 PISPIETVPVKLKPGMDGPRVKQWPLSEEKIKALTDICKEMEEEGKISRIGPENPYNTPI FAIKRKDGTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRTKNPEMVI CQYVDDLYVGSDLEIGQHRAKIEELRDHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKEHWTVNDIQKLVGKLNWASQIYAGIKVKQLCRLLRGAKALTDVVTMTEEAE LELAENREILREPVHGVYYDPTKDLIAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, G16E, L19I, K20I, M36I, R41K, H69K, K70R, I72T, L89M |
| >ZZR28| codons 1-99 PQITLWQRPLVTVRIEGQIIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILIEICGKRATGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Hawkins, CA | Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. | JAIDS, 2009 |
| Rhee, SY | Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration. | EBioMedicine, 2017 |