<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+TDF+NVP NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Y115F, M184V A62V V106A F227L T27S, K32R, V35T, T39S, K49R, W88C, I135V, S162A, K173A, Q174K, D177E, T200A, Q207E, V245K, D250E, K277R, K281R, L283I, V292I, I293V, S322A, I326V  
>ZZR109| codons 1-334
PISPIETVPVKLKPGMDGPKVKQWPLSEEKIRALTEICSEMEKEGKISRIGPENPYNTPV
FVIKRKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLKKKKSATVLDVGDAFFSVPL
DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRAKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPLLWMGYELHPDKWT
VQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIKVRQLCRLIRGTKALTEIVPLTEEAE
LELAENREILKEPVHGVYYDPAKDLVAEIQKQGQ

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13A, K14R, K20M, A22V, E35D, M36I, R41K, L63T, I64V, H69K, K70R, L89M  
>ZZR109| codons 1-99
PQITLWQRPLVTARIGGQLMEVLLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QITVEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

References
Author Title Citation
Hawkins, CA Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. JAIDS, 2009