Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| Q578 | ZZQ578 | Nigeria | 2007 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, T69~, Q151M | V75M, F77FL, K219R | Y181C | L34I, V35T, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, H221Y, V245Q, E248D, A272P, T286A, E291D, I293V, S322T, I326V |
| >ZZQ578| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKAITEICTEMEKEGKISKIGPENPYNTPV FAIKRKDS~KWRKLMDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQASMTKILEPFRTKNPEIVI CQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDRKYQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDVVPLTEEAE LELAENREILKEPVHGVYYDPTKDLVAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K14R, K20I, M36I, R41K, I64M, H69K, L89M |
| >ZZQ578| codons 1-99 PQITLWQRPLVTVRIGGQLIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QILMEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Hawkins, CA | Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. | JAIDS, 2009 |