Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4127 | CA16410 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T | 69 |
| 2 | 3TC+D4T+IDV | 61 |
| 3 | 3TC+D4T+NFV+NVP | 31 |
| 4 | 3TC+D4T+NFV+RTV+SQV | 69 |
| 5 | 3TC+ABC+APV | 50 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, V75T, M184V | A62V | K103N, Y181C | V35IT, A98S, D123E, Q174R, I178L, V179I, Q207E, R211K, V245Q, I293V, E297V |
| >CA16410| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKVTDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDLII CQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTVEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54ILM, I84V, L90M | V11I, F53FL | L10I, I13V, K20I, K55R, L63P, A71I, I72IT, Q92QKR |
| >CA16523| codons 1-99 PQITLWQRPIITVKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGLLRVRQYD QIPIEICGHKITGTVLVGPTPVNVIGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |