Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6574 | CA16408 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 39 |
| 2 | AZT+DDI | 78 |
| 3 | 3TC+D4T+IDV | 78 |
| 4 | AZT+NVP+RTV+SQV | 65 |
| 5 | ABC+APV+D4T+EFV | 61 |
| 6 | ABC+APV+D4T+EFV | 11 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219KN | K101KE, K103KN, Y181C, G190A | A98G | V60I, K122E, I135T, I142V, Q174K, G196E, E203EK, Q207E, L228HR, A288S, I293V |
| >CA16408| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLEKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIVI CQYMDDLYVASDLEIEQHRTKIKELREHLWRWGFYTPDNKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTEEAE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73AT | L10LI, N37S, L63P, V77I, I93L |
| >CA16521| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKAIATVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |