Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | K70KT, V75I, F77L, F116Y | Y181C, G190A | V35T, E36D, K49R, S68G, V90I, K101KT, D123E, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, F214L, P243PS, V245PQ, T286A, E291D, V292I, I293V, P294T, S322T, I326V |
| >ZZQ226| codons 1-334 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTDICTEMEKEGKISRIGPENPYNTPV FAIKRKDGTTWRKLIDLRELNKRTQDFWEIQLGIPHPAGLTKKKSVTVLDVGDAYYSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSPAIFQASMTKILEPFRTKNPEIVI CQYMDDLYVASDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT VQSIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKEPVHGVYYDPTKDLVAEIQKQGQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I13V, K20I, M36I, R41K, L63A, H69K, K70R, L89M |
| >ZZQ226| codons 1-99 PQITLWQRPLVTVKIGGQLIEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIAIEICGKRAIGTVLVGPTPVNIIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Hawkins, CA | Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. | JAIDS, 2009 |