Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6562 | CA16392 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 108 |
| 2 | 3TC+DDI | 31 |
| 3 | 3TC+DDI+NFV | 13 |
| 4 | 3TC+DDI+SQV | 78 |
| 5 | 3TC+D4T+NVP+SQV | 45 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | Y181C | K20R, V35I, I142V, D177E, G196E, R211G, A288S, P313PT, V317VA, D324DE, G333GE, Q334QL, M357MIT, A371AV, I375IV, A376ST, T386TA, A400T, V435E, D460DN, V467VI, S468SP, T470TA, K476KR, H483HY, K530KR, A554AS | R284RI |
| >CA16392| codons 1-560 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVGSDLEIEQHRTKIEELRQHLLGWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLIGTKSLTEVIPLTEEAE LELAENREILKETVHGAYYDPSKELIAEIQKQELGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKVTTESIVIWGKAPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP PLVKLWYQLEKEPIEGAETFYVDGAANRETKLGKAGYVTNRGRQKVIPLADTTNQRTELQ AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKERVYLAWVPAHK GIGGNEQVDKLVSSGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I62V, L63P, V77I, F99L |
| >CA16487| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |