Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1834 | CA16293 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 109 |
| 2 | D4T+DDI+RTV | 19 |
| 3 | D4T+DDC+NFV+RTV | 31 |
| 4 | D4T+NFV+RTV | 10 |
| 5 | D4T+IDV+NFV+RTV | 20 |
| 6 | D4T+NFV | 14 |
| 7 | 3TC+D4T+EFV+NFV | 32 |
| 8 | ABC+APV+D4T | 49 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IL, L76LV | L33F, Q58QE | I13V, K43KN, R57K, L63P, A71V, I93L |
| >CA16293| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADDTVFEEMNLPGRWNPKMIGGIGGFLKVKEYD QIPIEICGHKVIGTVVVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, L210LW, T215Y | K104N, D123E, I135T, I178M, T200A, Q207EG, R211K, P294Q, E297R, E298R, E300R | A299RS |
| >CA16022| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIQLTRRRR |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |