Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2314 | CA16264 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 30 |
| 2 | AZT+DDI | 52 |
| 3 | AZT+D4T | 8 |
| 4 | 3TC+RTV | 26 |
| 5 | 3TC+IDV+RTV+SQV | 30 |
| 6 | 3TC+D4T+NFV+NVP | 69 |
| 7 | 3TC+DDI+SQV | 26 |
| 8 | 3TC+D4T | 12 |
| 9 | 3TC+DDI+IDV+RTV | 17 |
| 10 | APV+AZT+D4T+DDI | 26 |
| 11 | 3TC+ABC+APV+IDV+RTV | 7 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33F, Q58E, G73C | L10I, I13V, K14KR, L19LI, E35D, M36L, N37D, R57K, I62V, L63P, T74S |
| >CA16264| codons 1-99 PQITLWQRPIVTVRIGGQIKEALLDTGADDTVFEDLDLPGRWKPKMIGGIGGFVKVKEYD QVPIEICGHKAICSVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K103N, Y181C | V108I, F227L | K20R, K43N, E44ED, K101KR, V118I, K122E, I135T, G196E, T200TA, E203K, H208HY, R211K, K223E, L228H, I293V, A304G |
| >CA16001| codons 1-304 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLRKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRAKIKELRQYLWKWGFYTPDNKHQEEPPLHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELG |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |