Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1264 | CA16259 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 17 |
| 2 | 3TC+AZT+SQV | 70 |
| 3 | 3TC+AZT+NFV | 21 |
| 4 | 3TC+D4T+RTV+SQV | 15 |
| 5 | 3TC+D4T+RTV+SQV | 75 |
| 6 | 3TC+D4T+DDI+EFV+RTV+SQV | 17 |
| 7 | 3TC+D4T+DDI+RTV+SQV | 18 |
| 8 | 3TC+D4T+RTV+SQV | 11 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, I84V | K43T, M46V | Q7H, L10I, I13V, I15V, K20T, E35D, L63P, I64V, V77I |
| >CA16259| codons 1-99 PQITLWHRPIVTVKVGGQLTEALLDTGADDTVLEDMNLPGRWTPKVIVGIGGFVKVRQYD QIPVEICGHKAIGTVLIGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V | V35RT, R83K, K122KE, I135V, K166R, Q207E, V245E, A272P, K277R, T286A, E297K |
| >CA15997| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |