Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA801 | CA16254 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 52 |
| 2 | 3TC+D4T+RTV | 13 |
| 3 | 3TC+D4T+IDV | 54 |
| 4 | D4T+DDI+RTV+SQV | 24 |
| 5 | 3TC+AZT+NFV | 21 |
| 6 | DDI+EFV+Unknown | 11 |
| 7 | 3TC+AZT+IDV+NVP+RTV | 85 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10LF, G73GS | I15IV, K20X, M36I, K55KR, R57K, I62V, L63P, A71V, I85IV |
| >CA16254| codons 1-99 PQITLWQRPFVTIKVGGQLXEALLDTGADDTVLEEINLPGRWKPKLIGGIGGFVRVKQYD QVPIEICGHKVISTVLVGPTPANIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69AD, M184MV, L210W, T215Y | V75VA, K219KE | K103N | V108VI | V35I, E40X, K43KE, V118I, D123E, I135T, S162CY, Q207E, H208X, R211K, L228H, Q242QP, T286A, I293V, E297K |
| >CA15992| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTXLEEEGKISKIGPENPYNTPV FAIKKKNSAKWRKLADFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREXLWKWGFYTPDEKHQKEPPFHWMGYELHPDKWT VPPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTKEAE |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |