Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6466 | CA16245 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | 3TC+AZT | 26 |
| 3 | 3TC+AZT+IDV | 83 |
| 4 | D4T+DDI+NVP | 74 |
| 5 | ABC+RTV+SQV | 40 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73C | L10I, T12S, I13IV, L19T, K20KR, E35D, M36I, I62V, L63P, I72V, I93L |
| >CA16245| codons 1-99 PQITLWQRPIVSVKIGGQTREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKAVCTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K238T | V35VI, S105A, K122E, I135T, R211K, I293V, E297R | T253TP |
| >CA15983| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKAVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDTWT VQPIVLPEKDSWPVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTREAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |