Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1127 | CA16213 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 157 |
| 2 | DDI | 4 |
| 3 | AZT+DDC | 52 |
| 4 | 3TC+AZT | 56 |
| 5 | 3TC+D4T+SQV | 22 |
| 6 | 3TC+D4T+IDV | 26 |
| 7 | 3TC+D4T+RTV+SQV | 115 |
| 8 | 3TC+D4T+IDV+SQV | 17 |
| 9 | 3TC+D4T+IDV | 31 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A | L10I, K20R, E35ED, M36I, N37D, R41K, I62IV, L63PS, I64L, A71V, I93L |
| >CA16213| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGKWKPKMIVGIGGFTKVRQYD QVPLEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215FV | K219Q | K20R, T69N, K102R, K122P, I135V, D177E, V179I, G196E, F214L, V245T, A272P, Q278H, T286A, I293IV, E297A |
| >CA15951| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGAKALTEVVPLTAEAE LEL |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |