Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6434 | CA16207 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ 3TC | 52 |
| 2 | NRTI | 108 |
| 3 | NFV+ DDI+ D4T | 113 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10X, I13IV, K14R, K20T, E35D, M36I, R41K, I62V, L63P, A71IT, T74S, Q92R, I93L |
| >CA16207| codons 1-99 PQITLWQRPXVTVRIGGQLTEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKIIGSVLVGPTPVNIIGRNLLTRLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M | A62V, V75I, F77L, F116Y | K20R, K32E, V35I, K49R, I135V, S162CW, E169D, Q207E, R211K, A272P, I293V |
| >CA15945| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIEALIEICTEMEKEGKISRIGPENPYNTPV FVIKKKDSTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYYSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSPAIFQCSMTKILDPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE L |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |