Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6406 | CA16169 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 48 |
| 2 | 3TC+AZT | 34 |
| 3 | 3TC+DDI | 5 |
| 4 | 3TC+DDI+RTV | 16 |
| 5 | D4T+DDC+NFV | 18 |
| 6 | D4T+DDC+NVP | 27 |
| 7 | 3TC+D4T+DDI+NFV+NVP | 15 |
| 8 | 3TC+AZT+NFV+NVP | 42 |
| 9 | 3TC+D4T+EFV+RTV+SQV | 3 |
| 10 | 3TC+D4T+RTV+SQV | 10 |
| 11 | 3TC+D4T+IDV+NFV | 38 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54A, V82A, L90M | K43T | L10I, I62V, L63P, I64V, V77I |
| >CA16169| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWTPKMIVGIGGFAKVRQYD QVPVEICGHKAIGTVLIGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74LI, M184V, L210W, T215Y | V75VA, K219E | K101E, Y181C, G190A | A98AG | P4S, V35L, E44D, L109LI, V118I, K122E, I135IV, G196E, D218E, L228H, S251I, A272AP, A288ST, I293V | A299AG |
| >CA15907| codons 1-303 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKIADFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVIDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIEQHRTKIEELRQHLWRWGFYTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDIWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTEEGE LEL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |