<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA2075 CA16143 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 75
2 DDI 45
3 DDC 40
4 3TC+AZT+IDV 79
5 3TC+DDC+NFV 26
6 3TC+RTV+SQV 2
7 D4T+DLV+SQV 39
8 3TC+AZT+DDI+RTV+SQV 9
9 3TC+AZT+DDI+SQV 23
10 3TC+APV+AZT 1
11 3TC+AZT 37

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M   L10I, K20M, E35D, M36I, N37K, R41K, L63P, A71T, I93L  
>CA16143| codons 1-99
PQITLWQRPIVTIKIGGQLMEALLDTGADDTVLEDIKLPGKWKPKIIGGIGGFIKVRQYD
QIPIEICGHKTIGTVLVGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74I, M184V, T215Y K219R K103N   K20R, K22R, K43KQ, E44D, K49R, E53D, T69N, A98S, V118I, D123E, S162D, K166R, E203K, Q207K, H208Y, L210F, R211E, K223E, L228R, A272S, L283I, I293V, P294A, E297K  
>CA15879| codons 1-298
PISPIETVPVKLKPGMDGPRVRQWPLTEEKIKALVEICTELEQDGKISRIGPDNPYNTPV
FAIKKKDSNKWRKIVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIKELRKYLFEWGFYTPDRKHQEEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLIRGTKALTEVVALTKE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Rhee, SY Predictive value of HIV-1 genotypic resistance test interpretation algorithms. J Infect Dis, 2009