Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6375 | CA16131 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 161 |
| 2 | D4T+DDI+NFV | 45 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46I | L10I, K14R, I15V, L63V, I93L |
| >CA16131| codons 1-99 PQITLWQRPIVTIRVGGQLKEALLDTGADNTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QIVIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | N348I | E6D, K43Q, E44ED, A98S, V118I, I135T, G196E, R211K, A272P, K277R, E291D, E297K, A304G, K311R, G359A, V365VI, K366R, I375IV, A376T, A400T, N418S, V435A, A437V, E449D, K451R, D460N, Q524E |
| >CA15868| codons 1-560 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDVIPLTKEAE LELGENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMRAA HTNDIRQLTEAVQKVTTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVSTP PLVKLWYQLEKEPIAGVETFYVDGAANRDTRLGKAGYVTNRGRQKVVSLTDTTNQKTELQ AIHLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVSQIIEELIKKEKVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |