Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6361 | CA16108 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 87 |
| 2 | AZT+DDI | 30 |
| 3 | 3TC+AZT+IDV | 205 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I | N88T | L10I, T12TS, I13IV, I15V, Q18H, L19I, K20I, K70R, A71V, I72ILM |
| >CA16108| codons 1-99 PQITLWQRPIVSVKVGGHIIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFIKVRQYD QILIEICGHRVMGTVLVGPTPVNIIGRTLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K20R, T39AS, K122E, Q207E, E248D, T286A, E297K | N265ND, E302E* |
| >CA15847| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICSELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLDWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE L*L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: Classification, amino acid mutation patterns, and prevalence in a northern California clinic-based population. | J Infect Dis, 2001 |