Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1144 | CA16107 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDI | 57 |
| 3 | AZT+DDI | 8 |
| 4 | AZT+DDC | 35 |
| 5 | 3TC+D4T | 13 |
| 6 | AZT+D4T+RTV+SQV | 57 |
| 7 | AZT+D4T+RTV+SQV | 31 |
| 8 | 3TC+D4T+NFV | 17 |
| 9 | 3TC+D4T+NFV+NVP | 52 |
| 10 | 3TC+D4T+NFV+NVP | 26 |
| 11 | 3TC+D4T+IDV+RTV | 27 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A, L90M | Q58E | L10V, K14R, F53Y, Q61E, I62V, L63P, A71V, T74S, V77I, I93L |
| >CA16107| codons 1-99 PQITLWQRPVVTIRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKLIVGIGGYVKVREYD EVPIEICGHKVIGSVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | G190GA | V35M, T69N, V118I, K122E, I135T, S162SG, V179VI, I202V, F214L, D237DE, A272P, K277R |
| >CA15846| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQGSMTKILEPFRKQNPDIII YQYVDDLYVASDLEIGQHRTKVEELRQHLLRWGLFTPDQKHQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |