Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6348 | CA16095 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 226 |
| 2 | AZT+D4T | 52 |
| 3 | 3TC+D4T+SQV | 39 |
| 4 | 3TC+D4T+RTV+SQV | 8 |
| 5 | 3TC+D4T+NFV | 143 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N88NS, L90M | L23LI, L33I, Q58E, G73GS | I13V, E35ED, M36IL, R57K, I62V, L63P, H69Y, A71V, I72T, V75VI, V82I, I93IL |
| >CA16095| codons 1-99 PQITLWQRPLVTVKIGGQLKEAILDTGADDTVIEDINLPGRWKPKMIGGIGGFIKVKEYD QVPIEICGYKVTSTILVGPTPINIIGRSLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219Q | K20R, T69N, K102R, K104R, K122E, D177DE, T215X, D218DE, P243X, V245E, A272P, V292I, I293V, E297K |
| >CA15832| codons 1-302 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKRSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFXTPEQKHQKEPPFLWMGYELHPDKWT VQXIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTKEAE LE |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |